Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction
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چکیده
منابع مشابه
Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction
Clinical radiation therapy for the treatment of CNS cancers leads to unintended and debilitating impairments in cognition. Radiation-induced cognitive dysfunction is long lasting; however, the underlying molecular and cellular mechanisms are still not well established. Since ionizing radiation causes microglial and astroglial activation, we hypothesized that maladaptive changes in astrocyte fun...
متن کاملCorrigendum: Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction
[This corrects the article on p. 42 in vol. 9, PMID: 27375429.].
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OBJECTIVE Adenosine monophosphate activated protein kinase (AMPK) has been identified as a regulator of vascular function via the preservation of endothelial cell (EC) function. In this study, we examined whether the beneficial effects of AMPK on ECs are dependent on its involvement in cholesterol efflux and its impact on hypercholesterolemia-induced endothelial dysfunction. METHODS AND RESUL...
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Objective—Adenosine monophosphate kinase (AMPK) has been identified as a regulator of vascular function via the preservation of endothelial cell (EC) function. We examined in this study whether the beneficial effects of AMPK on ECs are dependent on its involvement in cholesterol efflux and its impact on hypercholesterolemia-induced endothelial dysfunction. Methods and Results—Using human aortic...
متن کاملRadiation- induced cognitive impairments
Introduction: Ionizing radiation is non-surgical treatment of brain tumors and metastases. Preclinical studies have showed main insights into harmful effects of radiation on the nervous system in vivo and in vitro. Cognitive impairment such as progressive memory, executive and attention performance deficits indicates a significant risk for patients experiencing conventional rad...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Neuroscience
سال: 2016
ISSN: 1662-5099
DOI: 10.3389/fnmol.2016.00042